Born 15 May 1826
Sarah Elizabeth 1852- M. Henry Wise
Charles 10 May 1855-
1881 - Son Willam Henry Houser married Sarah Jane Snyder
Since George is not pictured, I think we can assume it was taken after 1887, and of course before Anna died in 1907. After analyzing the labels, I know it was taken after 1901 - Jennie Rebecca (Houser) Ernest was born in 1901. She looks to be 2 or 3 in this photo, so possibly the photo was taken in 1903.
Sometime after 1900 they went to Ohio. They are both buried there, and are found in the census there in 1910 and 1920. Address: 1153 Marcy St, Akron Ohio. (out of curiosity I checked the directory and found no Housers there. )